Characterization of Ancestral Origin of Cystic Fibrosis of Patients with New Reported Mutations in CFTR

<div>. Bar plot grouped by population identification. AFR: African ancestry; EUR: European ancestry; NAM: Native American ancestry; CF-EC: Ecuadorian cystic fibrosis patients. Three inferred clusters (<span class="nowrap"><svg height="8.8423pt" id="M6" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 31.1382 8.8423" width="31.1382pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M743 650H503L496 622L527 618C563 613 564 603 532 573C449 495 371 431 323 392C301 374 272 355 246 346L280 522C297 609 300 614 379 622L385 650H135L129 622C209 614 215 609 198 522L124 133C106 39 99 35 23 28L17 0H271L277 28C193 35 192 39 208 133L239 316C264 328 280 325 303 288C368 183 435 90 502 0H652L659 28C602 34 584 43 543 94C495 154 403 283 347 369L574 554C634 603 659 612 735 624L743 650Z"></path></g><g transform="matrix(.013,0,0,-0.013,13.449,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,24.712,0)"><path d="M285 378C315 398 338 416 353 432C373 451 384 474 384 503C384 579 325 635 236 635H235C182 635 136 610 108 579L65 516L85 496C110 533 150 575 205 575C258 575 300 543 300 481C300 407 232 369 141 339L147 310C163 315 188 321 211 321C268 321 338 284 338 192C338 94 288 40 217 40C160 40 119 68 93 91C85 98 77 97 69 91C60 84 47 71 46 58C44 46 48 35 62 22C75 10 116 -12 162 -12C234 -12 424 62 424 224C424 297 373 359 285 376V378Z"></path></g></svg>).</span></div>

BioMed Research International

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Figure 1

Figure 1: Characterization of Ancestral Origin of Cystic Fibrosis of Patients with New Reported Mutations in CFTR 