Research Article
Evaluation of the Role of Human DNAJAs in the Response to Cytotoxic Chemotherapeutic Agents in a Yeast Model System
Table 3
Sensitivity of the HSP40s expressing strains to chemotherapeutic agents and heat shock.
| | Strain | Doxorubicin | Cisplatin | Heat shock | | Survival (% ± SEM) | Sensitivity (fold) | Survival (% ± SEM) | Sensitivity (fold) | Survival (% ± SEM) | Sensitivity (fold) |
| | ydj1Δ | 6.4 ± 3.8 | 10 | 3.7 ± 2.0 | 7.3 | 0 ± 0 | — | | YDJ1 | 63.0 ± 7.8 | 1 | 27.0 ± 3.0 | 1.0 | 89 ± 26 | 1 | | DNAJA1 | 66.0 ± 5.0 | 1 | 38.0 ± 3.8 | 0.7 | 119 ± 5 | 0.7 | | DNAJA2 | 85.0 ± 8.0 | 0.7 | 72.0 ± 5.0 | 0.4 | 201 ± 24 | 0.4 | | DNAJA3 | 4.0 ± 3.0 | 15.8 | 1.0 ± 1.0 | 27.0 | 5 ± 5 | 18 | | DNAJA4 | 1.7 ± 2.0 | 37 | 4.0 ± 2.0 | 6.8 | 0 ± 0 | — |
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