Development and Validation of a Novel Model for Predicting the 5-Year Risk of Type 2 Diabetes in Patients with Hypertension: A Retrospective Cohort Study

Table 2

T2D risk prediction in patients with hypertension based on Cox proportional risk regression model.

	Univariate analysis	value	Multivariate analysis	value
	OR (95% CI)		OR (95% CI)
Age	1.04 (1.03, 1.06)	<0.0001	1.04 (1.02, 1.06)	0.0009
Gender
Male	Reference
Female	0.47 (0.25, 0.89)	NS
BMI	1.13 (1.07, 1.20)	<0.0001	1.14 (1.05, 1.23)	0.0016
FPG	6.60 (4.95, 8.81)	<0.0001	6.21 (4.28, 8.99)	<0.0001
TC	1.28 (1.04, 1.57)	0.0203	1.26 (1.07, 1.53)	0.0188
TG	1.29 (1.20, 1.39)	<0.0001	1.05 (0.86, 1.28)	NS
HDL-C	0.29 (0.15, 0.57)	0.0003	0.93 (0.33, 2.57)	NS
LDL-C	1.17 (0.85, 1.60)	NS
ALT	1.00 (1.00, 1.01)	NS
AST	1.01 (1.00, 1.02)	NS
BUN	1.13 (0.94, 1.36)	NS
CCR	0.99 (0.97, 1.00)	0.0458	1.00 (0.98, 1.02)	NS
Smoking status
Current	Reference		Reference
Ever	0.62 (0.27, 1.47)	NS	0.49 (0.20, 1.18)	NS
Never	0.32 (0.21, 0.51)	<0.0001	0.95 (0.44, 2.06)	NS
Drinking status
Current	Reference		Reference
Ever	0.17 (0.10, 0.29)	<0.0001	0.49 (0.20, 1.18)	NS
Never	0.16 (0.08, 0.32)	<0.0001	0.95 (0.44, 2.06)	NS
Family history
No	Reference		Reference
Yes	3.79 (2.33, 6.15)	<0.0001	1.63 (0.82, 3.23)	NS

T2D: type 2 diabetes; BMI: body mass index; FBG: fasting blood glucose; TC: total cholesterol; TG: triglycerides; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BUN: blood urea nitrogen; CCR: creatinine clearance; OR: odds ratio; CI: confidence interval; NS: no significance.