Research Article
Identification of an Individualized Prognostic Signature Based on the RWSR Model in Early-Stage Bladder Carcinoma
Table 3
Univariate and multivariate Cox regression analyses of the signature genes and overall survival.
| | Characters | Ch.description | Univariate analysis | Multivariate analysis | | HR (95% CI for HR) | value | HR (95% CI for HR) | value |
| | GEO | | | | | | | Sex | Female/male | 1.43 (0.76-2.7) | 2.58-01 | 1.13 (0.82-1.55) | 3.92-02 | | Age | >70/<=70 | 1.15 (1.02-1.14) | 9.03-03 | 1.17 (1.06-1.59) | 2.91-02 | | Invasiveness | Yes/no | 2.32 (1.46-3.92) | 1.64-03 | 1.35 (0.65-2.83) | 4.23-02 | | Intravesical therapy | Yes/no | 0.67 (0.48-0.93) | 1.59-02 | 0.91 (0.66-1.25) | 4.57-01 | | Stage | 0-III | 1.79 (1.37-2.23) | 2.23-04 | 1.39 (1.05-1.86) | 2.38-03 | | Grade | Low/high | 2.76 (1.68-4.57) | 1.97-03 | 1.21 (0.91-1.62) | 3.93-02 | | Event | Yes/no | 0.92 (0.51-1.6) | 7.76-01 | 0.46 (0.37-1.99) | 1.79-02 | | Specific survival | Alive/dead | 13.02 (7.54-24) | 6.62-04 | 11.79 (10.94-17.38) | 2.32-03 | | Risk score | Low/high | 4.45 (4.32-5.32) | 3.15-07 | 4.02 (4.99-8.04) | 2.46-04 | | TCGA | | | | | | | Sex | Female/male | 1.12 (0.73-1.68) | 7.04-03 | 2.95 (0.72-12.04) | 1.355-02 | | Age | >70/<=70 | 1.36 (0.76-2.35) | 3.77-02 | 1.22 (0.53-2.79) | 6.42-02 | | Height | >170/≤170 cm | 1.24 (0.99-2.5) | 2.43-03 | 1.09 (1.03-1.16) | 4.43-03 | | Weight | >80/≤80 | 0.99 (0.98-1.07) | 1.49-02 | 0.97 (0.93-1.05) | 2.97-02 | | Diagnosis age | Yes/no | 0.62 (0.33-1.89) | 4.16-02 | 0.83 (0.36-1.90) | 6.64-02 | | Stage | II/III | 1.62 (1.3-2.11) | 2.31-05 | 1.5 (0.92-2.58) | 9.92-04 | | Grade | High/low | 4.75 (3.63-7.91) | 9.92-02 | 3.8 (2.88-8.34) | 1.87-01 | | Noninvasive history | Yes/no | 0.81 (0.63-1.87) | 1.04-02 | 0.83 (0.43-1.57) | 5.68-02 | | Smoking | No/<15 yr/>15 yr | 1.41 (1.12-1.85) | 7.47-03 | 1.20 (0.67-2.15) | 5.53-03 | | Risk score | High/low | 3.93 (3.34-6.35) | 3.57-06 | 3.11 (3.09-4.24) | 8.42-04 |
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