Pharmacokinetic Effects of l-Tetrahydropalmatine on Ketamine in Rat Plasma by Ultraperformance Liquid Chromatography Tandem Mass Spectrometry

Table 3

Precision, accuracy, recovery, and matrix effect of KET and NK in rat plasma ().

Compound	Concentration ng/mL)	Precision (RSD %)		Accuracy (RE%)		Extraction recovery (%)	Matrix effect (%)
		Intraday	Interday	Intraday	Interday
KET	LLOQ (2.5)	3.15	2.95	-4.31	-5.54	—	—
	LQC (5)	2.72	4.31	-1.41	-8.11
	MQC (50)	3.34	2.60	-6.43	-5.23
	HQC (500)	2.62	2.82	-5.92	-6.51
NK	LLOQ (2.5)	4.38	5.12	-6.27	-7.11	—	—
	LQC (5)	5.75	6.53	-8.46	-7.02
	MQC (50)	3.71	4.41	-7.43	-9.28
	HQC (500)	2.50	2.66	-6.28	-6.07

RSD: relative standard deviation; RE: relative error; LLOQ: lower limit of quantitation; LQC: low-quality control; MQC: medium-quality control; HQC: high-quality control.