Pharmacokinetic Effects of l-Tetrahydropalmatine on Ketamine in Rat Plasma by Ultraperformance Liquid Chromatography Tandem Mass Spectrometry

Table 4

Stability of KET and NK in rat plasma at room temperature or freeze thaw.

Compound	Concentration (ng/mL)	12 h measured C (ng/mL)	RSD (%)	Freeze thaw	RSD (%)
KET	LQC (5)		3.96		5.28
	MQC (50)		5.98		2.31
	HQC (500)		2.13		3.56
NK	LQC (5)		3.50		4.54
	MQC (50)		5.29		3.56
	HQC (500)		2.81		4.98

LQC: low-quality control; MQC: medium-quality control; HQC: high-quality control.