Bioinformatical Analysis of miRNA-mRNA Interaction Network Underlying Macrophage Aging and Cholesterol-Responsive Difference between Young and Aged Macrophages

Table 2

Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of the differentially expressed miRNAs targets in response to cholesterol between aged and young macrophages.

Category	GO term	Description	Count	Genes
BP	GO:0006629	Lipid metabolic process	5	Stard4, Fdft1, Hsd17b7, Fasn, Acat2
	GO:0044255	Cellular lipid metabolic process	4	Stard4, Fdft1, Fasn, Acat2
	GO:0044281	Small molecule metabolic process	4	Fdft1, Hsd17b7, Fasn, Acat2
	GO:0008202	Steroid metabolic process	3	Stard4, Fdft1, Hsd17b7
	GO:0008610	Lipid biosynthetic process	3	Fdft1, Hsd17b7, Fasn
	GO:0044283	Small molecule biosynthetic process	3	Fdft1, Hsd17b7, Fasn
	GO:0055114	Oxidation-reduction process	3	Hsd17b7, Fasn, Acat2
	GO:0097384	Cellular lipid biosynthetic process	2	Fdft1, Fasn
	GO:0006695	Cholesterol biosynthetic process	2	Stard4, Fdft1
	GO:0008203	Cholesterol metabolic process	2	Fdft1, Hsd17b7
	GO:0030258	Lipid modification	2	Stard4, Acat2
	GO:0006631	Fatty acid metabolic process	2	Fasn, Acat2
MF	GO:0016407	Acetyltransferase activity	2	Fasn, Acat2
	GO:0016616	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2	Hsd17b7, Fasn
KEGG pathways	mmu01100	Metabolic pathways	4	Fdft1, Hsd17b7, Fasn, Acat2
	mmu01212	Fatty acid metabolism	2	Fasn, Acat2
	mmu00100	Steroid biosynthesis	2	Fdft1, Hsd17b7

Abbreviations: GO: gene ontology; BP: biological process; MF: molecular functioning; KEGG pathways: Kyoto Encyclopedia of Genes and Genomes pathways; NAD: nicotinamide adenine dinucleotide; NADP: nicotinamide adenine dinucleotide phosphate.