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| Egeberg et al. [17] | Chi et al. [16] |
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| Country of origin | Denmark | Taiwan |
| Study design | Cohort study | Cohort study |
| Year of publication | 2015 | 2017 |
| Cases | Cases of adults (18 years or older) with psoriasis were identified from the Danish National Patient Registry during 1 January 1997 to 31 December 2011. This registry covers all citizens of Denmark.
Diagnosis of psoriasis was made based on the presence of diagnostic codes of psoriasis (ICD-8 code of 696.10 or 696.19 or ICD-10 code of L40, which are codes for psoriasis in general) or the presence of at least two prescriptions of topical vitamin D derivatives in the absence of ICD-8 code of 696.09 or ICD-10 code of M070-M073, which are the codes for psoriatic arthritis.
Cases with diagnosis of uveitis prior to index date were not included. | Cases of psoriasis were identified from the National Health Insurance Research Database during 2000 to 2011. This registry covers 99% of the citizens of Taiwan.
Diagnosis of psoriasis was made based on the presence of diagnostic codes of psoriasis (ICD-9-CM code of 696, 696.1, or 696.8, which are codes for psoriasis in general), in the absence of ICD-9-CM code of 696.0, which is the code for psoriatic arthritis.
Cases with diagnosis of uveitis prior to index date were not included. |
| Comparators | Comparators were the rest of patients in the database who did not carry the diagnostic codes of psoriasis/psoriatic arthritis.
Comparators with diagnosis of uveitis prior to index date were not included. | Gender- and age-matched comparators without a diagnosis code for psoriasis were randomly selected from the 2005 Longitudinal Health Insurance Database, which is a random subset of one million enrollees in the National Health Insurance Research Database for the year 2005.
Comparators with diagnosis of uveitis prior to index date were not included. |
| Diagnosis of incident uveitis | The presence of the first diagnosis code for uveitis in the database after the index date. | The presence of the first diagnosis code for uveitis in the database after the index date (at least twice for outpatient visit or once for hospital admission). |
| Number of subjects (cases/comparators) | 74,129/5,434,749 | 147,954/147,954 |
| Percentage of female gender (cases/comparators) | 50.6/51.6 | 41.2/41.2 |
| Mean age in years (cases/comparators) | 40.7/43.3 | 44.4/44.4 |
| Follow-up | Until 31 December 2011, a diagnosis of end point, migration, or death from any causes. | Until incident uveitis, 31 December 2012, or withdrawal from the National Health Insurance program. |
| Confounder assessed in the multivariate analysis | Age, gender, socioeconomic status, and comorbidities | Age, gender, hypertension, dyslipidaemia, and diabetes |
| Quality assessment | Selection: 4 stars
Comparability: 1 star
Outcome: 3 stars | Selection: 4 stars
Comparability: 2 stars
Outcome: 3 stars |
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