Antiapolipoprotein A-1 Autoantibody Positivity Is Associated with Threatened Abortion

Table 1

Baseline characteristics of the overall cohort.

Demographics/biomarkers
Age at enrollment (years)	34 (31-37)
Ethnicity
Caucasian, (%)	333 (90.5)
Latin American, (%)	20 (5.4)
African, (%)	6 (1.6)
Indian, (%)	9 (2.4)
BMI (kg/m^2)	21 (20-24)
Weight gain at delivery (kg)	12 (10-15)
CRP (μg/mL)	3.35 (1.62-8.28)
Comorbidities
Thyroid disease, (%)	24 (6.5)
Hypertension, (%)	5 (1.3)
PCOS, (%)	7 (1.9)
Coagulopathies, (%)	7 (1.9)
Autoimmune diseases, (%)	25 (6.7)
Hashimoto thyroiditis, (%)	18 (4.9)
Basedow’s disease, (%)	1 (0.3)
SLE, (%)	2 (0.5)
Behçet syndrome, (%)	1 (0.3)
APS, (%)	1 (0.3)
Chronic gastritis, (%)	1 (0.3)
Multiple sclerosis, (%)	1 (0.3)
GDM, (%)	44 (11.9)
Therapy
Thyroid hormone replacement, (%)	21 (5.7)
Aspirin, (%)	13 (3.5)
Primary outcome
Threatened abortion, (%)	10 (2.7)
Anti-ApoA-1 IgG
Anti-ApoA-1 IgG positivity, (%)	31 (8.4)
Anti-ApoA-1, OD	0.39 (0.30-0.51)
Anti-Ac-terAA1 IgG positivity, (%)	82 (22.1)
Anti-Ac-terAA1 IgG, OD	0.45 (0.36-0.58)

Data are presented as a number and percentage of all cases or as median and interquartile range (IQR). Ac-terAA1 IgG: anti-c-terminus apoA-1 autoantibody; Anti-apoA-1 IgG: apoliprotein A-1 autoantibody; APS: antiphospholipid syndrome; BMI: body mass index; CRP: C-reactive protein; GDM: gestational diabetes mellitus; OD: optical density; PCOS: polycystic ovary syndrome; SLE: systemic lupus erythematosus.