Antiapolipoprotein A-1 Autoantibody Positivity Is Associated with Threatened Abortion
Table 2
Baseline characteristics of the overall cohort according to positivity/negativity for anti-ApoA-1 IgG autoantibodies.
Anti-ApoA-1 IgG negative ()
Anti-ApoA-1 IgG positive ()
Demographics/biomarkers
Age at enrollment (years)
34 (31-37)
32 (29-36)
0.082
Ethnicity
0.355
Caucasian, (%)
308 (90.9)
25 (86.2)
0.503
Latin American, (%)
18 (5.3)
2 (6.9)
0.665
African, (%)
6 (1.8)
0 (0)
1.000
Indian, (%)
7 (2.0)
2 (6.9)
0.153
BMI (kg/m2)
21 (20-24)
22 (20-26)
0.303
Weight gain at delivery (kg)
12 (10-15)
13 (9-18)
0.930
CRP (μg/mL)
3.36 (1.57-8.65)
2.72 (1.84-6.93)
0.715
Comorbidities
Thyroid disease, (%)
22 (6.5)
2 (6.5)
1.000
Hypertension, (%)
5 (1.5)
0 (0)
1.000
PCOS, (%)
7 (2.1)
0 (0)
1.000
Coagulopathies, (%)
7 (2.1)
0 (0)
1.000
Autoimmune diseases, (%)
23 (6.8)
2 (6.5)
1.000
Hashimoto thyroiditis, (%)
16 (4.7)
2 (6.5)
0.655
Basedow’s diseases, (%)
1 (0.3)
0 (0)
1.000
SLE, (%)
2 (0.6)
0 (0)
1.000
Behçet syndrome, (%)
1 (0.3)
0 (0)
1.000
APS, (%)
1 (0.3)
0 (0)
1.000
Chronic gastritis, (%)
1 (0.3)
0 (0)
1.000
Multiple sclerosis, (%)
1 (0.3)
0 (0)
1.000
GDM, (%)
39 (11.5)
5 (16.1)
0.450
Therapy
Thyroid hormone replacement, (%)
19 (5.6)
2 (6.5)
0.691
Aspirin, (%)
13 (3.8)
0 (0)
1.000
Pregnancy and delivery characteristics
Threatened abortion, (%)
7 (2.1)
3 (9.7)
0.042
Data are presented as a number and percentage (%) of all cases or as median and interquartile range (IQR). values have been calculated according to chi-square or Fisher’s exact test or Mann–Whitney test, as appropriate, and referred to as comparisons between study groups. Statistically significant correlations have been highlighted in bold character. Anti-ApoA-1 IgG: apoliprotein A-1 autoantibody; APS: antiphospholipid syndrome; BMI: body mass index; CRP: C-reactive protein; GDM: gestational diabetes mellitus; PCOS: polycystic ovary syndrome; SLE: systemic lupus erythematosus.
