Antiapolipoprotein A-1 Autoantibody Positivity Is Associated with Threatened Abortion
Table 3
Clinical characteristics of the cohort according to positivity/negativity for anti-c-terminus apoA-1 (Ac-terAA1) IgG autoantibodies.
Anti-Ac-terAA1 IgG negative ()
Ac-terAA1 IgG positive ()
Demographics/biomarkers
Age at enrollment (years)
34 (31-37)
33 (30-36)
0.256
Ethnicity
0.005
Caucasian, (%)
267 (92.7)
66 (82.5)
0.009
Latin American, (%)
14 (4.9)
6 (7.5)
0.402
African, (%)
4 (1.4)
2 (2.5)
0.615
Indian, (%)
3 (1.0)
6 (7.5)
0.004
BMI (kg/m2)
21 (20-24)
21 (20-24)
0.691
Weight gain at delivery (kg)
12 (11-16)
11 (9-15)
0.209
CRP (μg/mL)
3.32 (1.52-8.73)
3.78 (1.85-7.29)
0.936
Comorbidities
Thyroid disease, (%)
17 (5.9)
7 (8.5)
0.444
Hypertension, (%)
4 (1.4)
1 (1.2)
1.000
PCOS, (%)
6 (2.1)
1 (1.2)
1.000
Coagulopathies, (%)
7 (2.4)
0 (0)
0.356
Autoimmune diseases, (%)
18 (6.2)
7 (8.5)
0.458
Hashimoto thyroiditis, (%)
12 (4.2)
6 (7.3)
0.248
Basedow’s disease, (%)
1 (0.3)
0 (0)
1.000
SLE, (%)
1 (0.3)
1 (1.2)
0.394
Behçet syndrome, (%)
1 (0.3)
0 (0)
1.000
APS, (%)
1 (0.3)
0 (0)
1.000
Chronic gastritis, (%)
1 (0.3)
0 (0)
1.000
Multiple sclerosis, (%)
1 (0.3)
0 (0)
1.000
GDM
35 (12.2)
9 (11)
0.764
Therapy
Thyroid hormone replacement, (%)
16 (5.5)
5 (6.1)
0.791
Aspirin, (%)
12 (4.2)
1 (1.2)
0.313
Primary outcome
Threatened abortion, (%)
3 (1)
7 (8.5)
0.001
Data are presented as a number and percentage (%) of all cases or as median and interquartile range (IQR). values have been calculated according to chi-square or Fisher exact test or Mann–Whitney test, when appropriate, and referred to as comparisons between study groups. Statistically significant correlations have been highlighted in bold character. Anti-Ac-terAA1 IgG: anti-c-terminus ApoA-1 autoantibody; APS: antiphospholipid syndrome; BMI: body mass index; CRP: C-reactive protein; GDM: gestational diabetes mellitus; PCOS: polycystic ovary syndrome; SLE: systemic lupus erythematosus.
