Research Article
Metformin Inhibited Proliferation and Metastasis of Colorectal Cancer and presented a Synergistic Effect on 5-FU
Figure 5
Metformin and the combination of metformin and 5-FU inhibited the proliferation of CRC in vivo. (a). Immunohistochemical staining of Ki67 in each group. The images were observed under a magnification of 200x. (b). Quantification of Ki67-positive cells in each group. 1: control; 2: metformin; 3: 5-FU; 4: metformin+5-FU. compared with control group); △ compared with 5-FU group.
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