Effects of Cardiac Sympathetic Neurodegeneration and PPARγ Activation on Rhesus Macaque Whole Blood miRNA and mRNA Expression Profiles
Table 2
Differentially expressed small RNAs. Results shown here represent differential expression analysis without the outlier animal (Placebo 3). TMM, trimmed mean of M values; snoRNA, small nucleolar RNA; miRNA, micro RNA; FDR, false discovery rate.
Groups compared (Group A vs. Group B)
Differentially expressed RNA
RNA type
Group A TMM
Group B TMM
Fold change
Uncorrected value
FDR corrected value
12 weeks Placebo vs. pioglitazone
mml-miR-16-2-3p
miRNA
371.46
69.25
-5.36
0.0001555
0.0374679
mml-miR-204-5p
miRNA
35.53
9.53
-3.72
0.0003195
0.0384989
SNORA46 (ENSMMUG00000025257)
snoRNA
699.51
169.81
-3.81
0.0000211
0.0127114
Placebo Baseline vs. 12 weeks
mml-miR-16-2-3p
miRNA
114.74
326.76
2.31
0.0000004
0.0001542
mml-miR-133d-3p
miRNA
40.33
8.28
-3.32
0.0000052
0.0009051
mml-miR-1262-5p
miRNA
4.41
1.55
-2.58
0.0000467
0.0053706
Pioglitazone Baseline vs. 12 weeks
mml-miR-146b-5p
miRNA
4.54
9.70
2.20
0.0000418
0.0153731
SNORD15 (ENSMMUG00000026536)
snoRNA
1.70
5.80
2.42
0.0000004
0.0003415
TMM: trimmed mean of values; snoRNA: small nucleolar RNA; miRNA: microRNA; FDR: false discovery rate.
