Research Article
Effects of Cardiac Sympathetic Neurodegeneration and PPARγ Activation on Rhesus Macaque Whole Blood miRNA and mRNA Expression Profiles
Table 3
GO enrichment analysis of mml-miR-16-2-3p target genes. Note that no Cellular Component GO terms were statistically significant. GO, gene ontology.
| | Significant GO enrichment category | Number of mml-miR-16-2-3p target genes in the enrichment category | FDR adjusted
value |
| | Biological process | Regulation of transcription, DNA-templated (GO:0006355) | 367 | 0.00000019832 | | Regulation of gene expression (GO:0010468) | 246 | 0.00001071521 | | Regulation of cellular macromolecule biosynthetic process (GO:2000112) | 162 | 0.00001511050 | | Nervous system development (GO:0007399) | 122 | 0.00006220983 | | Regulation of nucleic acid-templated transcription (GO:1903506) | 153 | 0.00008303183 | | Regulation of transcription from RNA polymerase II promoter (GO:0006357) | 324 | 0.00008778663 | | Positive regulation of transcription, DNA-templated (GO:0045893) | 246 | 0.00241166240 | | Positive regulation of transcription from RNA polymerase II promoter (GO:0045944) | 193 | 0.00249008012 | | Transcription from RNA polymerase II promoter (GO:0006366) | 120 | 0.00297232330 | | Negative regulation of transcription, DNA-templated (GO:0045892) | 185 | 0.00319111007 | | Protein phosphorylation (GO:0006468) | 112 | 0.02744139610 | | Protein modification by small protein conjugation (GO:0032446) | 97 | 0.03163906572 |
| | Molecular function | Ubiquitin-like protein ligase activity (GO:0061659) | 55 | 0.01261271587 | | Ubiquitin protein ligase activity (GO:0061630) | 54 | 0.01261271587 | | Ubiquitin-protein transferase activity (GO:0004842) | 100 | 0.01261271587 | | Integrin binding (GO:0005178) | 31 | 0.03275663844 |
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GO: gene ontology.
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