Research Article
Quercetin Downregulates Cyclooxygenase-2 Expression and HIF-1α/VEGF Signaling-Related Angiogenesis in a Mouse Model of Abdominal Aortic Aneurysm
Table 1
The primer sequences for the qPCRs in Materials and Methods.
| | Gene | Forward | Reverse |
| | VEGF-A | 5-GTAACGATGAAGCCCTGGAGT-3 | 5-TGTTCTGTCTTTCTTTGGTCTGC-3 | | ICAM-1 | 5-CTCGTGATGGCAGCCTCTTAT-3 | 5-GGCTTGTCCCTTGAGTTTTATG-3 | | VCAM-1 | 5-AGTGTTGCTTGGACTGACTGTTG-3 | 5-GACCTCTTTACCGTTTGCCTAT-3 | | VE-cadherin | 5-ATCTCAGACAACGGCAATCC-3 | 5-GAAAATTGCCACCAGTGCTT-3 | | TGF1 | 5-GCCCAGCACTTTTTGATTACTA-3 | 5-AGGTTGATTGGTGTCTGAGCA-3 | | FGF | 5-TTGTGTCTATCAAGGGAGTGTGTG-3 | 5-AGTATTTCCGTGACCGGTAAGTAT-3 | | COX-2 | 5-TGCTGGAAAAGGTTCTTCTACG-3 | 5-GAACCCAGGTCCTCGCTTAT-3 | | HIF-1α | 5-AAAGAACTAAACACACAGCGGA-3 | 5-ACAAATCAGCACCAAGCACG-3 | | MMP-2 | 5-AAGGATGGACTCCTGGCACATGCCTTT-3 | 5-ACCTGTGGGCTTGTCACGTGGTGT-3 | | MMP-9 | 5-AAGGACGGCCTTCTGGCACACGCCTTT-3 | 5-GTGGTATAGTGGGACACATAGTGG-3 | | GAPDH | 5-GGTTGTCTCCTGCGACTTCA-3 | 5-TGGTCCAGGGTTTCTTACTCC-3 |
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Abbreviations: VEGF-A: vascular endothelial growth factor-A; ICAM-1: intercellular adhesion molecule-1; VCAM-1: vascular cell adhesion molecule 1; VE-cadherin: vascular endothelial cadherin; TGF1: transforming growth factor-1; FGF: fibroblast growth factor; COX-2: cyclooxygenase-2; HIF-1α: hypoxia-inducible factor 1α; MMP: matrix metalloproteinase.
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