BioMed Research International / 2020 / Article / Fig 3

Research Article

Inhibition of the CDK4/6-Cyclin D-Rb Pathway by Ribociclib Augments Chemotherapy and Immunotherapy in Renal Cell Carcinoma

Figure 3

Differential effects of ribociclib on the CDK4/6-cyclin D-pRb signaling in RCC. (a) The representative western blot photo shows decreased and unchanged level of p-Rb at two phosphorylation sites in sensitive () and resistant () RCC cell lines, respectively. (b) The decreased and unchanged transcriptional level of E2F target genes: FOXM1, CCNE1, and MSH6 in RCC cell lines. Cells were treated with ribociclib for 24 hours prior to western blot and mRNA level analysis. , compared to control.

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