Research Article

A Predictive Model for Tumor Invasion of the Inferior Vena Cava Wall Using Multimodal Imaging in Patients with Renal Cell Carcinoma and Inferior Vena Cava Tumor Thrombus

Table 2

Univariable associations of multimodal image parameters predicting vascular wall invasion.

FeaturesIVC invasion
Yes ()No ()

Median (IQR)
Age, 60.0 (52.3, 63.8)61.0 (53.3, 66.0)-0.4850.627
AP diameter renal vein30.1 (25.6, 34.4)24.1 (21.3, 28.9)-0.1020.271
Maximum IVC AP diameter, mm34.1 (29.2, 40.4)26.4 (22.1, 32.0)-3.824<0.001
IVC AP diameter at the RVo, mm30.1 (25.6, 34.4)24.1 (22.3, 28.9)-3.887<0.001
Contralateral renal vein AP diameter at the RVo, mm10.4 (8.3, 12.1)9.1 (7.9,10.9)-1.6770.930
Maximum coronal IVC diameter, mm2.117<0.001
Coronal IVC diameter at the RVo, mm0.830<0.001
Maximum AP diameter of renal vein02930.867
(%)
Sex3.9580.047
 Male30 (75.0)25 (54.3)
 Female10 (25.0)21 (45.7)
Side of tumor0.0061.000
 Right29 (72.5)33 (71.7)
 Left11 (27.5)13 (28.3)
Tumor thrombus level10.4710.015
 Mayo I3 (7.5)14 (30.4)
 Mayo II16 (40.0)20 (43.6)
 Mayo III14 (35.0)6 (13)
 Mayo IV7 (17.5)6 (13)
Pathological type2.0360.361
 Clear cell renal cell carcinoma28 (70.0)38 (82.6)
 Papillary renal cell carcinoma7 (17.5)4 (8.7)
 Other5 (12.5)4 (8.7)
Vascular wall invasion by pathological examination5.0700.031
 No26 (65.0)39 (84.8)
 Yes12 (30.0)5 (10.9)
 Unsure2 (5.0)2 (4.3)
Bland thrombus in the IVC on CT/MRI19.822<0.001
 No15 (62.5)39 (84.8)
 Yes25 (37.5)7 (15.2)
Complete IVC occlusion at the RVo on CT/MRI12.825<0.001
 No5 (12.5)21 (45.7)
 Yes34 (80.5)21 (45.7)
 Unsure1 (2.5)4 (8.6)
Residual IVC blood flow on ultrasound19.873<0.001
 No33 (82.5)16 (34.8)
 Yes7 (17.5)30 (65.2)

IVC: inferior vena cava; AP: anterior-posterior; IVCTT: IVC tumor thrombus; RVo: renal vein ostium; CT/MRI: computed tomography/magnetic resonance imaging; indicates statistical significance.