The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer

Figure 7

The STEAPs involved pathways based on KEGG analysis. (a) STEAP1 and STEAP2 are predicted to be involved in mineral absorption. (b) STEAP3 is predicted to participate in the processes of TP53-regulating transcription of cell death genes and ferroptosis. Abbreviations: CTR1: copper transporter member 1; MT: metallothionein-1; ATP7P: ATPase copper transporting alpha; ATOX1: antioxidant 1 copper chaperone; TFR1: transferrin receptor; TF: transferrin; ZIP8: zinc transporter member 8; DMT1: ferrous ion membrane transport protein DMT1; ROS: ROS protooncogene 1.

(a)

(b)