Serum miR-1228-3p and miR-181a-5p as Noninvasive Biomarkers for Non-Small Cell Lung Cancer Diagnosis and Prognosis

Table 3

GO analysis of target genes.

Function enrichment	FDR	Target
Go biological process (BP)
GO:0006355: Regulation of transcription, DNA-dependent	4.51E-119	621
GO:0045893: Positive regulation of transcription, DNA-dependent	7.41E-46	204
GO:0045944: Positive regulation of transcription from RNA polymerase II promoter	3.83E-45	232
GO:0006915: Apoptotic process	3.61E-41	229
GO:0045892: Negative regulation of transcription, DNA-dependent	9.24E-39	174
GO:0000122: Negative regulation of transcription from RNA polymerase II promoter	1.65E-37	176
GO:0007165: Signal transduction	2.73E-36	353
GO:0010467: Gene expression	5.03E-34	168
GO:0006468: Protein phosphorylation	2.91E-33	164
GO:0044419: Interspecies interaction between organisms	1.12E-32	144
Go cellular component(CC)
GO:0005634: Nucleus	0	2024
GO:0005737: Cytoplasm	0	1859
GO:0005634: GO:0005737: Nucleus, cytoplasm	5.851E-210	975
GO:0005829: Cytosol	5.38E-155	813
GO:0005730: Nucleolus	5.43E-134	606
GO:0005634: GO:0005730: Nucleus, nucleolus	2.29E-129	584
GO:0005737: GO:0005829: Cytoplasm, cytosol	9.11E-123	606
GO:0005622: Intracellular	1.24E-108	685
GO:0016020: Membrane	9.19E-97	1104
GO:0005654: Nucleoplasm	1.86E-95	394
Go molecular function(MF)
GO:0005515: Protein binding	0	1770
GO:0046872: Metal ion binding	9.92E-150	975
GO:0000166: Nucleotide binding	1.10E-134	771
GO:0003677: DNA binding	7.10E-134	688
GO:0008270: Zinc ion binding	1.24E-115	693
GO:0046872: GO:0008270: Metal ion binding, zinc ion binding	3.22E-108	648
GO:0005524: ATP binding	8.41E-97	550
GO:0005515: GO:0000166: Protein binding, nucleotide binding	6.55E-95	363
GO:0005524: GO:0000166: ATP binding, nucleotide binding	4.73E-89	506
GO:0003677: GO:0005515: DNA binding, protein binding	8.64E-80	278