Abnormal Levels of Liver Enzymes and Hepatotoxicity in HIV-Positive, TB, and HIV/TB-Coinfected Patients on Treatment in Fako Division, Southwest Region of Cameroon

Table 3

Different categories (grade) of hepatotoxicity with respect to weeks of follow-up.

Variable	Subclass	Baseline (%)	Week 1 (%)	Week 4 (%)	Week 8 (%)	Week 12 (%)
ALT levels	Normal	125 (100.0)	109 (87.2)	107 (85.6)	100 (80.0)	49 (63.6)
	Grade 1	—	13 (10.4)	14 (11.2)	15 (12.0)	20 (26.0)
	Grade 2	—	03 (2.4)	04 (3.2)	10 (8.0)	08 (10.4)
	Mean ALT (±SEM)
AST levels	Normal	125 (100.0)	74 (59.2)	82 (65.6)	89 (71.2)	40 (52.0)
	Grade 1	—	44 (35.2)	34 (27.2)	18 (14.4)	27 (35.0)
	Grade 2	—	07 (5.6)	09 (7.2)	18 (14.4)	10 (8.0)
	Mean AST (±SEM)
GGT levels	Normal	125 (100.0)	100 (80.0)	93 (74.4)	109 (87.2)	57 (74.0)
	Grade 1	—	18 (14.4)	25 (20.0)	09 (7.2)	19 (24.7)
	Grade 2	—	6 (4.8)	6 (4.8)	07 (5.6)	01 (1.3)
	Grade 3	—	1 (0.8)	1 (0.8)	—	—
	Mean GGT (±SEM)
ALP levels	Normal	125 (100.0)	113 (90.4)	101 (80.8)	120 (96.0)	66 (85.7)
	Grade 1	—	11 (8.8)	19 (15.2)	05 (04.0)	11 (14.3)
	Grade 2	—	1 (0.8)	5 (4.0)	—	—
	Mean ALP (±SEM)
TBili levels	Normal	125 (100.0)	99 (79.2)	111 (88.8)	97 (77.6)	59 (76.6)
	Grade 1	—	14 (11.2)	7 (5.6)	10 (8.0)	11 (14.3)
	Grade 2	—	3 (2.4)	5 (4.0)	13 (10.4)	07 (9.1)
	Grade 3	—	4 (3.2)	—	02 (1.6)	—
	Grade 4	—	5 (4.0)	2 (1.6)	03 (2.4)	—
	Mean TBili (±SEM)
Type of liver injury	Normal	125 (100.0)	105 (84.0)	117 (93.6)	104 (83.2)	73 (94.8)
	Hepatocellular	—	—	—	—	—
	Cholestatic	—	20 (16.0)	08 (6.4)	21 (16.8)	04 (5.2)
	Mixed	—	—	—	—	—
	Mean factor (±SEM)
Alcohol-related LI	GGT:	125 (100.0)	116 (92.8)	113 (90.4)	121 (96.8)	77 (100.0)
	GGT:	0 (00.0)	09 (7.2)	12 (9.6)	04 (3.2)	0 (00.0)
	Total	125	125	125	125	77