Deletion of Bmal1 Impairs Pancreatic β-Cell Function via Mitochondrial Signaling Pathway

Figure 1

Bmal1 deficiency impaired glucose-stimulated insulin secretion in INS-1 cells. INS-1 cells were incubated with or without Bmal1 inhibition. Insulin concentration was detected by the ELISA method. (a) Presented the mean insulin secretion in response to 2.8 mmol/L glucose. (b) Presented the mean insulin secretion in response to 16.7 mmol/L glucose. NC: normal control group; siRNA-NC: INS-1 cells treated with negative control siRNA; siRNA-Bmal1: INS-1 cells treated with Bmal1 siRNA. A value < 0.05 is considered as statistically significant. , , and .

(a)

(b)