Deletion of Bmal1 Impairs Pancreatic β-Cell Function via Mitochondrial Signaling Pathway

Figure 4

Bmal1 deficiency altered mitochondrial architecture in β-cells. Images were obtained at magnifications of 5000x. (a, b) Most mitochondria were round or oval with intact membrane and a few tubular and vesicular cristae. (b) Most mitochondria were swollen with irregular shape and fracture and disappearance of mitochondrial cristae. NC: normal control group; siRNA-NC: INS-1 cells treated with negative control siRNA; siRNA-Bmal1: INS-1 cells treated with Bmal1 siRNA.

(a) NC

(b) siRNA-NC

(c) siRNA-Bmal1