Quantitative Diagnosis of Atrophic Gastritis by Probe-Based Confocal Laser Endomicroscopy

Figure 1

Imaging of gastric mucosa under histology and pCLE. The pCLE images of normal gastric mucosa showed round pit patterns as well as subepithelial capillaries surrounded by honeycomb-like structures in the corpus (Figure 1(a)) and rhabditiform pit patterns and coil-shaped network of capillaries in antrum (Figure 1(b)). The subepithelial capillaries were highlighted because of the flowing of fluorescein within the vessels (black line in Figure 1(c)). In inflammatory mucosa, the fluorescein sodium permeated into the interstitial space and showed the highlighted space among the glands (black line in Figure 1(d)). Among the lesions diagnosed as NAG ((f) in corpus and (h) in antrum) and CAG ((j) in corpus and (l) in antrum) by histology, the pCLE images showed increased distance between glands (interstitial space between two adjacent glands, red lines). (e) and (g) show increased distance between glands in corpus and antrum in NAG group. (i) and (k) show that in CAG group.

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