Prostate Health Index and Prostate Health Index Density as Diagnostic Tools for Improved Prostate Cancer Detection
Table 5
Area under the receiver operating characteristic curve for prostate cancer biomarkers and logistic regression models.
Biomarker
Overall PCa
Clinically significant PCa
According to Epstein’s criteria
ISUP
AUC (95% CI) value
AUC (95% CI) value
AUC (95% CI) value
tPSA (ng/mL)
0.56 (0.48-0.64) 0.119
0.65 (0.57-0.72) 0.000
0.58 (0.48-0.68) 0.110
PSAD (ng/mL/cc)
0.72 (0.65-0.79) 0.000
0.78 (0.72-0.85) 0.000
0.68 (0.59-0.78) 0.000
fPSA (ng/mL)
0.62 (0.55-0.70) 0.002
0.62 (0.54-0.70) 0.003
0.62 (0.52-0.72) 0.003
%fPSA
0.68 (0.61-0.75) 0.000
0.76 (0.69-0.83) 0.000
0.71 (0.63-0.80) 0.000
p2PSA (pg/mL)
0.52 (0.44-0.60) 0.576
0.52 (0.44-0.61) 0.60
0.54 (0.44-0.64) 0.60
%p2PSA
0.68 (0.61-0.75) 0.000
0.70 (0.63-0.77) 0.000
0.72 (0.64-0.80) 0.000
phi
0.72 (0.65-0.79) 0.000
0.77 (0.71-0.84) 0.000
0.77 (0.69-0.84) 0.000
PHID
0.77 (0.70-0.83) 0.000
0.80 (0.74-0.86) 0.000
0.75 (0.66-0.83) 0.000
Base model
0.75 (0.69-0.82) 0.000
0.81 (0.74-0.87) 0.000
0.74 (0.65-0.83) 0.000
Base model +p2PSA
0.78 (0.72-0.84) 0.000
0.83 (0.77-0.89) 0.000
0.78 (0.70-0.86) 0.000
Base model +%p2PSA
0.78 (0.71-0.84) 0.000
0.82 (0.76-0.88) 0.000
0.78 (0.70-0.86) 0.000
Base model +phi
0.78 (0.72-0.84) 0.000
0.83 (0.76-0.89) 0.000
0.79 (0.71-0.87) 0.000
Base model +PHID
0.77 (0.71-0.84) 0.000
0.80 (0.74-0.87) 0.000
0.75 (0.66-0.83) 0.000
Abbreviations: AUC: area under the receiver operating curve; CI: confidence interval; fPSA: free prostate-specific antigen; %fPSA: free to total PSA ratio; ISUP: International Society of Urological Pathology; OR: odds ratio; PCa: prostate cancer; %p2PSA: p2PSA to fPSA ratio; phi: Prostate Health Index; PHID: phi density; PSAD: PSA density; tPSA: total PSA.
