Protective Effects of Aminooxyacetic Acid on Colitis Induced in Mice with Dextran Sulfate Sodium

Figure 2

AOAA alleviated DSS-induced colitis in mice and restored mRNA expression of epithelial barrier. (a) Colonic sections were stained with H&E (original magnification ×200). (b) Histopathological scores of colonic sections. The mRNA expression of (c) ZO-1, (d) occludin, (e) claudin-1, (f) E-cadherin, and (g) vimentin. (h) The expressions of these proteins were tested by immunohistochemistry in experimental colitis in mice. One representative experiment of three is shown. Data are represented as () (^# vs. the H₂O+PBS group; , , and vs. the DSS+PBS group).

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