miR-149 Suppresses the Proliferation and Metastasis of Human Gastric Cancer Cells by Targeting FOXC1

Figure 4

FOXC1 is upregulated in gastric cancer. (a) Expression analysis of FOXC1 expression in GC tissues () and normal tissues () was performed in TCGA database. (b, c) immunohistochemistry and qRT-PCR showed that FOXC1 expression significantly increased in GC tissues compared with that in normal gastric tissues (). (d) qRT-PCR was performed to analyze the FOXC1 expression in GC cell lines (AGS MKN28, BGC-823, MKN45, and SGC-7901) and GES-1 cells. Differences between groups were evaluated using Student’s -test, and data are expressed as . For all data, indicates , and indicates .

(a)

(b)

(c)

(d)