Research Article

Identification of Potential Genetic Biomarkers and Target Genes of Peri-Implantitis Using Bioinformatics Tools

Table 3

Top 10 hub genes that were closely associated with the results of GO and KEGG analyses.

TermGenes

GO:0006955~immune responseCCR1, XBP1, CXCL8, GPR65, AQP9, NCF4, CXCL1, SERPINB9, SAMHD1, THBS1, LAX1, C3, IL-6, IGKC, RGS1, IL-1β, PXDN, ENPP2, CD27, CD36, CCL18, TLR4, HLA-DQB1
GO:0006954~inflammatory responseCCR1, CXCL8, CD180, CYBB, CXCR4, CXCL1, PTGS2, THBS1, PIK3CG, C3, IL-6, THEMIS2, CXCR1, IL-1β, SPP1, C3AR1, CD27, CD14, CCL18, TLR4
GO:0007165~signal transductionCD53, GABRP, SH3GL3, CSF3R, CXCL8, CXCL1, ABCC9, HTR3A, ARHGAP15, LYVE1, C3, EVI2A, CHL1, RGS1, IL-1β, MRC1, PECAM1, TNFRSF17, CD38, CCL18
GO:0007155~cell adhesionNLGN4Y, CCR1, CSF3R, LAMB4, TNC, FN1, LYVE1, THBS1, CTGF, THEMIS2, SELL, FAP, CHL1, BOC, SPP1, PECAM1, CNTN1, SLAMF7, CD36
GO:0007186~G-protein-coupled receptor signaling pathwayCXCL8, GPR34, GPR65, CXCR4, CXCL1, AREG, PIK3CG, C3, SFRP4, SFRP2, CXCR1, RGS1, C3AR1, ENPP2, CCL18, ADGRL4, TGM2
GO:0005886~plasma membraneCSF3R, GPR65, AQP9, SLC2A3, TREM1, PIK3CG, CTGF, RGS5, RGS2, CHL1, RGS1, BOC, MRC1, ENPP2, C3AR1, CD38, CD36, LRRFIP1, TGM2, GUCY1A3, CD53, IFNAR2, FCER1G, FCRL5, ANXA3, DCC, CYBB, RHOH, HTR3A, ABCC9, PRLR, LAX1, CDHR1, PECAM1, SLC27A6, PLIN2, MAPT, DSC1, TLR4, HLA-DQB1, SLC47A2, NPR3, KCNA3, CXCR4, SAMHD1, SLC7A2, RASGRP3, P2RY8, C3, CD79A, IGKC, CXCR1, GPC3, SLAMF7, TNFRSF17, SLAMF6, CD14, CCR1, MSR1, GABRP, IL-10RA, MERTK, LYVE1, PTPRC, FCGR2A, DLG2, SELL, FAP, VNN2, CD207, CNTN1, CD27, ADGRL4, CDK14, F2RL2, CD200
GO:0016021~integral component of membraneCSF3R, DENND5B, GPR65, AQP9, LRMP, SLC2A3, TREM1, AREG, MS4A4A, AADACL2, CHL1, ENPP2, C3AR1, CD38, CD36, UTY, GUCY1A3, CD53, IFNAR2, ST6GAL1, FCER1G, GPR34, FCRL5, DCC, CYBB, HTR3A, ABCC9, PRLR, LAX1, SFRP4, SFRP2, CDHR1, PECAM1, SLC27A6, CFAP54, DSC1, HLA-DQB1, SLC47A2, NPR3, CXCR4, SEL1L3, P2RY8, CD79A, CXCR1, SLITRK3, SLAMF7, TNFRSF17, SLAMF6, CCR1, MSR1, GABRP, XBP1, IL-10RA, MERTK, LYVE1, SCIMP, TMEM156, PTPRC, FCGR2A, EVI2A, SELL, FAP, CD207, ESYT3, EVI2B, ADGRL4, F2RL2, CD200
GO:0070062~extracellular exosomeKPRP, SH3GL3, NPR3, CXCR4, PLAT, SLC2A3, THBS1, C3, IGKC, CHL1, GPC3, SPP1, CTSH, CD38, SLAMF6, CD14, TGM2, CD53, SERPINB4, SERPINB1, ST6GAL1, KRT3, ANXA3, KRT2, FN1, KLK14, SERPINB9, KRT76, LYVE1, MMP-9, ALDH1A3, PTPRC, FCGR2A, FABP4, IL-1β, PXDN, MGP, PI15, PECAM1, CNTN1, CD27, DSC1, MS4A1
GO:0005615~extracellular spaceCXCL8, TNC, PLAT, CXCL1, THBS1, AREG, CTGF, C3, SRPX2, IGKC, GPC3, SPP1, ENPP2, CTSH, CD14, CD36, CCL18, NLGN4Y, SRGN, IFNAR2, SERPINB4, SERPINB1, KRT2, MMP-3, FN1, KLK14, SERPINB9, IGFL1, MERTK, MMP-9, SFRP4, IL-6, SFRP2, FAP, TCN1, IL1-β, PXDN, PECAM1, MS4A1, BPIFC
GO:0005576~extracellular regionCSF3R, OLFML2B, CXCL8, LUZP2, TNC, PLAT, CXCL1, TREM1, THBS1, CTGF, C3, AADACL2, IGKC, SPP1, LIPM, LIPK, CD14, SRGN, IFNAR2, MMP-1, MMP-3, FN1, MMP-9, PRLR, MFAP5, GZMK, SFRP4, IL-6, SFRP2, FNDC1, TCN1, IL-1β, MZB1, CD27, PLIN2, SPINK9, F2RL2, PNLIPRP3
GO:0004872~receptor activityGUCY1A3, NLGN4Y, CSF3R, IL-10RA, CD180, MRC1, TNFRSF17, TREM1, TLR4, LYVE1, CD200
GO:0004252~serine-type endopeptidase activityGZMK, C3, IGKC, FAP, MMP-1, MMP-3, KLK14, CTSH, PLAT, MMP-9
GO:0002020~protease bindingSERPINB4, XBP1, SELL, FAP, CHL1, FN1, SERPINB9
GO:0000977~RNA polymerase II regulatory region sequence-specific DNA bindingMEF2C, XBP1, HLF, ELF5, EAF2, ZFY, BARX2
GO:0004888~transmembrane signaling receptor activityCD79A, EVI2A, DCC, MRC1, CD27, TLR4, LYVE1
hsa04060:cytokine-cytokine receptor interactionCCR1, IFNAR2, CSF3R, CXCL8, IL-10RA, CXCR4, CXCL1, PRLR, IL-6, CXCR1, IL-1β, TNFRSF17, CD27, CCL18
hsa05200:pathways in cancerIL-6, CSF3R, CXCL8, MMP-1, DCC, LAMB4, FN1, CXCR4, PTGS2, MMP-9, PIK3CG, RASGRP3
hsa05146:amoebiasisSERPINB4, IL-6, SERPINB1, CXCL8, IL-1β, LAMB4, FN1, SERPINB9, CD14, TLR4, PIK3CG
hsa04145:phagosomeC3, MSR1, FCGR2A, NCF4, MRC1, CD14, CD36, NOS1, THBS1, TLR4, HLA-DQB1
hsa04151:PI3K-Akt signaling pathwayIFNAR2, IL-6, CSF3R, LAMB4, SPP1, TNC, FN1, THBS1, PRLR, TLR4, PIK3CG