Natural Killer T Cells in Various Mouse Models of Hepatitis

Figure 1

Activation of iNKT cells mainly occurs through one of two signals: T cell receptor (TCR) signaling provided by foreign lipid antigens or proinflammatory cytokine signaling (such as IL-12) produced by PRR-mediated activation of APCs. The TCR signal provided by a self-lipid antigen is also required in physiological conditions. Figure created with BioRender (https://biorender.com). Abbreviations: TCR: T cell receptor; NKT: natural killer T cell; IL: interleukin; APC: antigen-presenting cell; TLR: toll-like receptor; PRR: pattern recognition receptor.