Ameliorative Effects of Gallic Acid on Cisplatin-Induced Nephrotoxicity in Rat Variations of Biochemistry, Histopathology, and Gene Expression

Figure 4

H&E staining of renal tissues, magnification ×100. (a) Control group, light microscopy examination of renal tissues in control group showed normal structure of glomerulus, renal cortex, and interstitium with no evidence of acute cell necrosis. Photomicrograph of a renal section taken from Gallic acid-supplemented rats had almost normal structure of glomerulus, renal cortex, and interstitium without acute necrosis (b–d). But photomicrograph of a renal section taken from cisplatin-treated rats showing marked vacuolization, necrosis of tubular cells, protein cast, and congestion of vessels (e). Photomicrograph of a renal section taken from Gallic acid-supplemented cisplatin-treated rats showing that treatment with Gallic acid remarkably attenuated renal tissue injury (f).

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