Ameliorative Effects of Gallic Acid on Cisplatin-Induced Nephrotoxicity in Rat Variations of Biochemistry, Histopathology, and Gene Expression

Table 1

Morphologic and histopathological renal parameters of the control group and experimental groups. Diameter of glomeruli and thickness of proximal convoluted tubules were analyzed by one-way ANOVA and expressed by . Other parameters were analyzed with Kruskal-Wallis test and expressed by median (min–max).

Groups	Diameter of glomeruli, μm ()	Thickness of proximal convoluted tubules, μm ()	Cell necrosis, median (min, max)	Eosinophilic casts, median (min, max)	Vacuolization, median (min, max)	Congestion, median (min, max)	Hemorrhage, median (min, max)	Leukocyte infiltration, median (min, max)
Control	()	()	0.50 (0.00, 1.00)	0.00 (0.00, 0.00)	0.00 (0.00, 0.00)	0.50 (0.00, 1.00)	0.00 (0.00, 1.00)	0.00 (0.00, 0.00)
Gallic acid	()	()	0.50 (0.00, 1.00)	0.00 (0.00, 0.00)	0.00 (0.00, 1.00)	0.00 (0.00, 0.00)	0.00 (0.00, 0.00)	0.00 (0.00, 1.00)
Cisplatin	()	()	3.00 (3.00, 3.00)	1.00 (1.00, 2.00)	1.00 (1.00, 2.00)	1.00 (1.00, 3.00)	1.00 (0.00, 1.00)	1.00 (0.00, 1.00)
Gallic acid+Cisplatin	()	()	1.00 (0.00, 2.00)	0.00 (0.00, 0.00)	0.00 (0.00, 1.00)	0.50 (0.00, 1.00)	0.00 (0.00, 1.00)	0.00 (0.00, 1.00)
value	Cnt vs. cis (0.0624); Cis vs. cis-gal (0.2633); Cnt vs. gal (0.5135)	Cnt vs. cis (0.0022); Cis vs. cis-gal (0.077); Cnt vs. gal (0.1246)	Cnt vs. cis (0.006); Cis vs. cis-gal (0.001); Cnt vs. gal (1.000)	Cnt vs. cis (0.006); Cis vs. cis-gal (0.001); Cnt vs. gal (1.000)	Cnt vs. cis (0.006); Cis vs. cis-gal (0.008); Cnt vs. gal (0.686)	Cnt vs. cis (0.164); Cis vs. cis-gal (0.101); Cnt vs. gal (0.343)	Cnt vs. cis (0.412); Cis vs. cis-gal (0.234); Cnt vs. gal (0.686)	Cnt vs. cis (); Cis vs. cis-gal (0.234); Cnt vs. gal (0.686)