Crosstalk between Heart Failure and Cognitive Impairment via hsa-miR-933/RELB/CCL21 Pathway

Figure 3

Protein interaction networks mapped from DE-miRNA, DE-mRNA, and predicted miRNA target gene prediction sites. (a) miRNA-TF-mRNA-regulated protein interaction network. (b, c) The top 2 aggregator network modules predicted according to MCODE. It represents the core group of genes involved in the disease process. The rectangles represent general protein mRNAs, the inner quadrilateral represents TF, and the rhombus represents miRNAs.

(a)

(b)

(c)