Crosstalk between Heart Failure and Cognitive Impairment via hsa-miR-933/RELB/CCL21 Pathway

Figure 8

Volcano plot of DE-mRNA and DE-miRNA and Sankey plot of miRNA-TF-mRNA. (a) Volcano plots show the presence of DE-miRNAs in cognitive impairment and normal controls. The marked circles are for DE-miRNAs cooccurring in HF and cognitive impairment, present in both the cognitive impairment prediction model and the core PPI subnetwork. The miRNAs in the larger font are those miRNAs cooccurring in the cognitive impairment prediction model and the PPI subnetwork. (b) Volcano plot depicts DE-mRNA expression in cognitive impairment and normal controls. The marked circles are the DE-mRNAs targeted by miRNAs, which cooccur in HF and cognitive impairment and cooccur in the cognitive impairment prediction model and PPI subnetwork. (c) Mulberry diagram exhibits DE-miRNAs cooccurring in the model and core network and the regulatory axis of their target TF/mRNA.