The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier

Figure 2

lncRNAs regulate the intestinal mucosal barrier directly (directly regulating TJ protein or AQPs) or indirectly (through miRNAs or other intermediates). The destruction of intestinal mucosal barrier participates in the progression of intestinal diseases such as IBD, colorectal cancer, and celiac disease through immune inflammatory reaction, toxin invasion, and flora translocation.