The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier

Table 1

Regulatory effect and mechanism of different lncRNAs on intestinal mucosal mechanical barrier.

lncRNA	Impact on the barrier	Regulation methods	Action object	Functions
H19	↓	Direct	Paneth cell and goblet cell	Promote autophagy of small intestinal mucosa [25].
	↓	Indirect	miR-675	Inhibit the expression of TJ ZO-1 and E-cadherin, resulting in epithelial barrier dysfunction [27].
H19	↑	Indirect	miRNA LET-7G	Promote the repair of intestinal epithelial mucosa after burn [29].
	↑	Direct	AQP1, AQP3	Promote the expression of AQP and maintain the stability of intestinal mucosal mechanical barrier [32].
	↑	Indirect	P53, miRNA34a, let-7	Promote IECs proliferation and epithelial regeneration [33].
	↑	Indirect	miR-675-5p	Intestinal mucosal barrier damage caused by inhibition of VDR expression [36].
CCAT1	↓	Indirect	miR-185-3p	Increase the permeability of intestinal barrier and destroy the function of intestinal barrier [43].
PlncRNA1	↑	Direct	MAZ, ZO-1, occludin	Significantly enhance the protective function of intestinal barrier against sodium sulfate paste (DSS) injury [48].
neat1	↓	Direct	IEC macrophages	Participate in inflammatory response by regulating intestinal epithelial barrier and exocrine-mediated macrophage polarization [52].
SPRY4-IT1	↑	Direct	TJ	Change the expression of tight junction (TJ) protein to enhance the function of intestinal epithelial barrier [59].
uc.173	↑	Indirect	miRNA195 miR-29b	Promote the translation of TJ claudin-1 (CLDN1) and the repairment of intestinal mucosal mechanical barrier [61].
Bmp1	↑	Indirect	miR-128-3p	Increase the proliferation and migration of IEC-6 or HIEC-6 cells in rat intestinal crypt epithelial cells and promote the repair of intestinal mucosal mechanical barrier [65].
BC012900	↓	Direct	IECs	Inhibit the proliferation of intestinal epithelial cells and increase the sensitivity of cells to apoptosis [66].