The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier

Table 2

Summary and mechanism of lncRNA as a marker for diagnosis and treatment of various intestinal diseases.

Intestinal disease	Related lncRNA	Regulating mechanism	A potential role as a marker of diagnosis or treatment
IBD	CNN3-206	The lncRNA CNN3-206-miR-212-Caspase10 regulatory network	In intestinal lesions of patients with Crohn’s disease, the expression of lncRNA CNN3-206 is significantly increased [74].
	CRNDE	miR-495 and SOCS1	Indirectly induce apoptosis of intestinal mucosal epithelial cells and aggravate the inflammatory response of IBD, can be used as a potential therapeutic target [75].
	NAIL	p38 and NFκB	Targeted knockout of NAIL can inhibit the expression of downstream inflammatory factors and greatly reduce the intestinal inflammatory response in patients with IBD [102].
Colorectal cancer	CCAT-1	miR-185-3p; Claudin, ZO-1	In patients with colorectal cancer, the expression of CCAT is significantly increased, and the intestinal barrier function can be significantly improved by inhibiting its expression [42].
	SPRY4-IT1	Claudin-1, claudin-3, occludin, and jam-1	SPRY4-IT1 can destroy intestinal TJ and cause intestinal epithelial barrier dysfunction, which can be used as a potential therapeutic target [84].
	UC.173	miR-29b	Promoting the expression of uc.173 can advance the translation of TJ, claudin-1 (CLDN1), promotes the repair of intestinal mucosal mechanical barrier, and is beneficial to the improvement of symptoms in patients with colorectal cancer [61].
IBS-D	H19	AQP 1, 3, 8	Inhibiting H19 expression can significantly promote AQP1, AQP3, and AQP8 expression and significantly improve intestinal barrier function in IBS-D mice [87].
Celiac disease	Lnc13	hnRNPD	The expression of LNC13 in intestinal biopsies of patients with celiac disease was significantly decreased, suggesting that the downregulated expression of LNC13 may be one of the causes of inflammation of celiac disease [91].
	HCG14	NOD1	The content of HCG14 in intestinal tract of patients with celiac disease increased significantly, suggesting its potential value as a diagnostic index of celiac disease [93].