Identification of Novel Choroidal Neovascularization-Related Genes Using Laplacian Heat Diffusion Algorithm

Figure 1

Entire procedures to identify novel choroidal neovascularization- (CNV-) related genes. A protein-protein interaction network reported in STRING is employed. Laplacian heat diffusion (LHD) with validated CNV-related genes as seed nodes is applied to such network for extracting raw candidate genes. They are further filtered by a postprocessing method, resulting in eleven candidate genes. These genes were extensively analyzed.