PTHR1 Genetic Polymorphisms Are Associated with Osteoporosis among Postmenopausal Arab Women
Table 1
Anthropometric and biochemical characteristics of the subjects according to the study groups.
Parameters
CG N = 300
PMO N = 300
P- value
P- value
General characteristics
Age (year)
53.9 ± 6.1
57.8 ± 7.9
<0.001
BMI (kg/m2)
34.3 ± 5.9
31.5 ± 6.3
<0.001
Menopause status (≥10 years)
50 (17.7)
129 (45.3)
<0.001
0.001
-score and BMD
-score AP spine #
<0.001
<0.001
-score femur
<0.001
<0.001
BMD spine (g/mm2)
<0.001
<0.001
BMD femur (g/mm2)
<0.001
<0.001
Bone turnover markers
25(OH)D (nmol/l)
61.1 (37.8-84.5)
66.3 (39.1-93.0)
0.20
0.70
PTH (pg/ml)
12.31 (7.59-21.05)
15.41 (7.81-34.98)
0.10
0.40
OPG (pg/ml)
752.1 (523.9-995.3)
853.6 (617.8-1150.7)
0.037
0.43
OPN (ng/ml)
2.32 (1.26-3.36)
2.70 (1.46-4.10)
0.11
0.57
RANKL (pg/ml)
33.18 (18.51-61.02)
28.88 (21.77-48.30)
0.50
0.33
β-CTx (ng/ml)
0.07 (0.04-0.11)
0.07 (0.04-0.11)
0.59
0.83
Osteocalcin (ng/ml)
8.89 (3.2-13.13)
9.16 (3.45-14.19)
0.58
0.72
Inflammatory markers
Interleukins
IL-4 (pg/ml)
7.04 (3.92-10.33)
4.47 (2.52-9.35)
0.012
0.06
IL-1β (pg/ml)
1.72 (0.39-2.72)
1.64 (0.33-2.69)
0.38
0.17
Adipocytokines
Leptin (ng/ml)
16.14 (7.36-33.1)
20.27 (8.3-34.23)
0.32
0.15
Growth factors
TGF-β (ng/ml)
40.26 (31.47-52.24)
37.58 (18.10-48.56)
0.048
0.019
Note: data presented as for normal variables while the median (quartile 1–quartile 3) presented for nonnormal variables; #nonnormal variables; value < 0.05 considered significant, indicates adjusted value for age and BMI.
