PTHR1 Genetic Polymorphisms Are Associated with Osteoporosis among Postmenopausal Arab Women
Table 3
Comparison of BTMs levels according to PTHR1 rs1138518 genotypes in the study groups.
Parameters
PTHR1 rs1138518
values
values
CG
PMO
Genotype T/T
25(OH)D (nmol/l)
58.2 (39.6-81.0)
81.2 (60.8-101.7)
0.02
0.04
PTH (pg/ml)
12.1 (6.5-26.1)
15.2 (6.7-48.1)
0.67
0.74
OPG (pg/ml)
866.3 (621.2-1081.7)
744.6 (558.4-979.4)
0.36
0.65
OPN (pg/ml)
2505.2 (1334.6-3121.7)
3181.5 (1825.4-4863.1)
0.18
0.28
RANKL (pg/ml)
40.6 (23.3-68.3)
32.8 (25.4-77.6)
0.96
0.96
β-CTx (ng/ml)
0.1 (0.0-0.1)
0.1 (0.0-0.1)
0.46
0.58
Osteocalcin (ng/ml)
5.8 (2.9-14.5)
7.1 (1.8-13.5)
0.036
0.09
Genotype C/T
25(OH)D (nmol/l)
66.4 (43.5-87.8)
59.9 (36.7-92.4)
0.51
0.048
PTH (pg/ml)
12.2 (7.9-17.8)
17.8 (10.6-69.6)
0.016
0.10
OPG (pg/ml)
719.8 (471.5-887.6)
854.9 (609.3-1056.2)
0.07
0.54
OPN (pg/ml)
2298.0 (1397.7-2952.2)
2651.6 (1706.7-3986.1)
0.12
0.66
RANKL (pg/ml)
32.0 (13.4-65.5)
29.0 (21.6-48.2)
0.84
0.87
β-CTx (ng/ml)
0.1 (0.0-0.1)
0.1 (0.1-0.2)
0.70
0.80
Osteocalcin (ng/ml)
8.6 (3.2-12.5)
10.7 (4.8-15.3)
0.023
0.23
Genotype C/C
25(OH)D (nmol/l)
60.6 (36.6-82.6)
65.9 (41.8-87.1)
0.24
0.52
PTH (pg/ml)
12.3 (8.4-26.7)
13.6 (6.9-27.5)
0.738
0.55
OPG (pg/ml)
752.1 (513.6-1168.1)
826.7 (641.3-1227.7)
0.252
0.44
OPN (pg/ml)
2356.5 (804.5-3482.8)
1812.1 (689.1-3424.8)
0.458
0.67
RANKL (pg/ml)
33.9 (18.4-62.2)
27.9 (21.2-48.2)
0.535
0.40
β-CTx (ng/ml)
0.1 (0.0-0.1)
0.1 (0.0-0.1)
0.690
0.48
Osteocalcin (ng/ml)
9.4 (3.4-13.6)
8.0 (3.5-12.9)
0.699
0.75
Note: data presented as for normal variables while median (Q1–Q3) for nonnormal variables; considered significant. Adjusted value for adjustment for multiple comparisons.
