Development of a Population Pharmacokinetic Model for Cyclosporine from Therapeutic Drug Monitoring Data

Figure 1

Diagnostic evaluations of the final model for CsA. (a) Observed CsA concentrations vs. population (left plot) and individual (right plot) predictions. (b) Normalized prediction distribution errors (NPDE) vs. time in hours (top plot) and vs. individual prediction CsA concentrations in ng/mL (bottom plot). (c) Prediction corrected visual predictive check (pcVPC) plot for the final model of CsA. Visual predictive check for the final model of CsA shows the observed concentrations (ng/mL) of CsA (circles), the 50th percentile along with the 10th and 90th (blue lines) percentiles of the observed concentration data, and the simulated confidence intervals for each percentile (red and blue shaded areas for the median and 5th and 95th, respectively).

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