Establishment and Validation of the Detection of TERT Promoter Mutations by Human Gliomas U251 Cell Lines

Figure 5

The percentage of MGMT methylation and Ki-67 protein expression in four gliomas subgroups. MGMT methylation was enriched in the IDH-mut/TERTp-mut subgroup, and the percentage of Ki-67 protein expression was the highest in the IDH-wt/TERTp-mut subgroup. MGMT: O6-methylguanine-DNA methyltransferase; TERTp: the promoter region of the telomerase reverse transcriptase gene; IDH: isocitrate dehydrogenase; mut: mutation; wt: wild-type.