Research Article
Association between Periodontitis and Carotid Artery Calcification: A Systematic Review and Meta-Analysis
Table 2
Subgroup and sensitivity analysis.
| | No. of studies | Heterogeneity | Model | Meta-analysis | (%) | | OR | 95% CI |
| Subgroup analysis | Definition of periodontitis | Secure | 4 | 76.6 | 0.005 | Random | 2.02 | 1.18-3.45 | Insecure | 4 | 77.4 | 0.004 | Random | 10.78 | 4.41-26.34 | Diagnosis of CAC | | | | | | | PR | 5 | 82.7 | <0.001 | Random | 2.46 | 1.36-4.45 | CT/CBCT/DS | 3 | 84.5 | 0.002 | Random | 14.14 | 3.67-54.53 | Degree of periodontitis | Severe | 3 | 95.7 | <0.001 | Random | 6.40 | 1.03-39.78 | Moderate | 3 | 80.6 | 0.006 | Random | 2.43 | 1.04-5.70 | Severe-moderate | 8 | 88.6 | <0.001 | Random | 4.42 | 2.28-8.58 |
| Sensitivity analysis | Low-quality studies excluded | 5 | 79.2 | 0.008 | Random | 3.92 | 1.98-7.73 | Tiller (2011) excluded | 7 | 90.1 | <0.001 | Random | 4.52 | 2.13-9.55 | Kamak (2015) excluded | 7 | 88.9 | <0.001 | Random | 4.19 | 2.03-8.62 | Alsakr (2020) excluded | 7 | 89.9 | <0.001 | Random | 4.47 | 2.08-9.57 | Bilgin (2020) excluded | 7 | 89.9 | <0.001 | Random | 5.34 | 2.61-10.90 | Dewake (2020) excluded | 7 | 86.50 | <0.001 | Random | 3.56 | 1.91-6.64 | Gustafsson (2019) excluded | 7 | 89.8 | <0.001 | Random | 5.05 | 2.24-11.42 | Paju (2020) excluded | 7 | 86.8 | <0.001 | Random | 5.348 | 2.64-10.81 | Ravon (2003) excluded | 7 | 88.6 | <0.001 | Random | 4.42 | 2.28-8.57 |
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