Research Article
The Correlations between Clinical Features, Dermoscopic and Histopathological Findings, and Treatment Outcomes of Patients with Pitted Keratolysis
Table 3
Associations between dermoscopic-histopathological findings and improvement of foot odor and lesions after 2 months of treatment.
| | Foot odor | Foot lesions | No improvement () | Improvement () | value | No improvement () | Improve ment () | value |
| Clinical findings at baseline | | | | | | | Severity of foot odor (VAS)ǂ | | | 0.29 | | | 0.04 | Mean quality-of-life scoreǂ | | | 0.04 | | | 0.05 | Involvement area (% of total foot area) | 41.7 | 53.3 | 0.26 | 40.5 | 55.7 | 0.12 | Dermoscopic findings | | | | | | | Pit | 4 (66.7) | 19 (90.5) | 0.15 | 6 (75.0) | 17 (89.5) | 0.56 | Size | | | | | | | Same | 1/4 (25.0) | 10/19 (52.6) | 0.32 | 2/6 (33.3) | 9/17 (52.9) | 0.64 | Mixed | 3/4 (25.0) | 9/19 (47.4) | | 4/6 (66.7) | 8/17 (47.1) | | Configuration | | | | | | | Same | 0 | 7/19 (36.8) | 0.27 | 1/6 (16.7) | 6/17 (35.3) | 0.62 | Mixed | 4/4 (100.0) | 12/19 (63.2) | | 5/6 (83.3) | 11/17 (64.7) | | Arrangement | | | | | | | Clustered | 0 | 3/19 (15.8) | 1.00 | 1/6 (16.7) | 2/17 (11.8) | 1.00 | Scattered | 4/4 (100.0) | 16/19 (84.2) | | 5/6 (83.3) | 15/17 (88.2) | | Characteristics | | | | | | | Geometric | 2/4 (50.0) | 1/19 (5.3) | 0.07 | 1/6 (16.7) | 2/17 (11.8) | 1.00 | Interrupted dermatoglyphic lines | 4/4 (100.0) | 16/19 (84.2) | 1.00 | 6/6 (100) | 14/17 (82.4) | 0.54 | Bead sign | 0 | 5/19 (26.3) | 1.00 | 2/6 (33.3) | 3/17 (17.6) | 0.58 | White opaque | 1 (16.7) | 4 (19.0) | 1.00 | 1 (12.5) | 4 (21.1) | 1.00 | Black/brown opaque | 1 (16.7) | 1 (4.8) | 0.40 | 2 (25) | 0 | 0.02 | Histopathological findings | | | | | | | Pits | 6 (100.0) | 20 (95.2) | 1.00 | 8 (100.0) | 18 (94.7) | 1.00 | Parakeratosis | 2 (33.3) | 2 (9.5) | 0.21 | 2 (25.0) | 2 (10.5) | 0.56 | Color alteration of keratin | 6 (100.0) | 16 (76.2) | 0.56 | 8 (100.0) | 14 (73.7) | 0.11 | Presence of bacteria | 5 (83.3) | 19 (90.5) | 0.55 | 8 (100.0) | 16 (84.2) | 0.53 | Location of bacteria | | | | | | | Only at the walls of pits | 1/5 (20.0) | 14/19 (73.7) | 0.05 | 3/8 (37.5) | 12/16 (75.0) | 0.04 | At the walls and bases of pits | 4/5 (80.0) | 5/19 (26.3) | | 5/8 (62.5) | 4/16 (25.0) | |
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was statistically significant. ǂ The statistics are presented as . Abbreviation: VAS: visual analogue score. |