Prognostic Value of BIM Deletion in EGFR-Mutant NSCLC Patients Treated with EGFR-TKIs: A Meta-Analysis

Table 5

Meta-analysis of BIM deletion polymorphism associated with response to EGFR-TKIs.

Response	No. of studies	BIM deletion/total	(%)	Pooled OR	95% CI
ORR
Overall	14	289/1844	30.4	0.60	0.42-0.85	0.004
China	8	173/1147	1.9	0.50	0.35-0.71	<0.001
Others	6	116/697	40.4	0.85	0.45-1.59	0.605
DCR
Overall	12	248/1588	0	0.59	0.38-0.90	0.014
China	8	173/1147	0	0.48	0.30-0.77	0.002
Others	4	75/441	0	1.40	0.52-3.75	0.504

ORR: objective response rate; DCR: disease control rate; OR: odds ratio.