Dexmedetomidine Directs T Helper Cells toward Th1 Cell Differentiation via the STAT1-T-Bet Pathway

Figure 1

Dexmedetomidine induces Th1 cell differentiation in CD4+ T cells. CD4+ T cells were incubated with anti-CD3/CD28 and rIL-2 for 3 days. Then, different concentrations of dexmedetomidine (0, 0.01, 0.1, 1, and 10 nM) were added to stimulate CD4+ T cells for another 24 hours. Th1 and Th2 cell concentrations were measured (a) and analyzed (b) as described in Methods and Material. The data are representative of at least three independent experiments with consistent results. Student’s -test was performed to detect between-group differences. The results shown are the . , .

(a)

(b)