Formulation, Optimization, In Vitro and In Vivo Evaluation of Saxagliptin-Loaded Lipospheres for an Improved Pharmacokinetic Behavior

Table 1

Compositions of different liposphere formulations and the obtained outcomes of percentage yield, entrapment efficiency, and SG release from lipospheres.

Formulations	Formulation components (actual level % )			Responses ()
	BA	T-80	SS	PY	EE	DR
F1	2.00	1.50	3000
F2	3.00	0.50	2250
F3	2.00	0.50	1500
F4	3.00	1.50	2250
F5	2.00	1.00	2250
F6	1.00	1.00	1500
F7	1.00	0.50	2250
F8	2.00	0.50	3000
F9	2.00	1.00	2250
F10	2.00	1.50	1500
F11	2.00	1.00	2250
F12	1.00	1.50	2250
F13	2.00	1.00	2250
F14	3.00	1.00	3000
F15	3.00	1.00	1500
F16	2.00	1.00	2250
F17	1.00	1.00	3000

: 1.681; BA: behenic acid; SS: stirring speed; PY: percentage yield; EE: entrapment efficiency; DR: drug release, .