Full Genomic Sequences of H5N1 Highly Pathogenic Avian Influenza Virus in Human Autopsy Specimens Reveal Genetic Variability and Adaptive Changes for Growth in MDCK Cell Cultures

Table 1

Demographical patient information and H5N1 viral genomic sequences.

Patient	Location	Virus origin^1	Virus name	Segment	GenBank accession no.
A 59-year-old man	Nong Bua Lam Phu Province, northeast of Thailand	Autopsy tissue organs	A/Thailand/NBL1/2006 (H5N1)-Lung	PB2, PB1, PA, HA, NP, NA, M, NS	MG668928-MG668935
			A/Thailand/NBL1/2006 (H5N1)-Trachea	PB2, PB1, PA, HA, NP, NA, M, NS	MG668920-MG668927
			A/Thailand/NBL1/2006 (H5N1)-Fecal specimen	PB2, PB1, PA, HA, NP, NA, M, NS	MG668912-MG668919
			A/Thailand/NBL1/2006 (H5N1)-Colon	PB2, PB1, PA, HA, NP, NA, M, NS	MG668904-MG668911
		Virus isolates	A/Thailand/NBL1/2006 (H5N1)–L^2	PB2, PB1, PA, HA, NP, NA, M, NS	GQ466176-GQ466183
			A/Thailand/NBL1/2006 (H5N1)–T^3	PB2, PB1, PA, HA, NP, NA, M, NS	KJ907475-KJ907482
			A/Thailand/NBL1/2006 (H5N1)–F^4	PB2, PB1, PA, HA, NP, NA, M, NS	KJ907467-KJ907474

Note: ¹full-genome sequencing from direct specimens was obtained by using next-generation sequencing (NGS) with the GS Junior platform (Roche Diagnostics, Basel, Switzerland), meanwhile full-genome sequencing from virus isolates were obtained by Sanger DNA sequencing method. ²Virus isolate from the lung. ³Virus isolate from the trachea. ⁴Virus isolate from the fecal specimen.