Prognostic Significance of Preoperative Fibrinogen-to-Prealbumin Ratio in Patients with Stage I–III Colorectal Cancer Undergoing Surgical Resection: A Retrospective Cohort Study

Table 1

The correlations between the FPR and clinicopathological factors.

Variable	Case (584)	FPR
		Low (357)	High (227)
Sex				0.796	0.372
Male	363 (62.2%)	227 (63.6%)	136 (59.9%)
Female	221 (37.8%)	130 (36.4%)	91 (40.1%)
Age (years)				2.877	0.004
BMI				-3.385	0.001
Diabetes mellitus				3.513	0.061
Negative	553 (94.7%)	343 (96.1%)	210 (92.5%)
Positive	31 (5.3%)	14 (3.9%)	17 (7.5%)
Hypertension				2.114	0.146
Negative	492 (84.2%)	307 (86.0%)	185 (81.5%)
Positive	92 (15.8%)	50 (14.0%)	42 (18.5%)
Cardiovascular disease				0.096	0.757
Negative	570 (97.6%)	349 (97.8%)	221 (97.4%)
Positive	14 (2.4%)	8 (2.2%)	6 (2.6%)
Depth of invasion				1.178	0.278
T1-2	164 (28.1%)	106 (29.7%)	58 (25.6%)
T3-4	420 (71.9%)	251 (70.3%)	169 (74.4%)
Lymph node status				4.197	0.123
N0	341 (58.4%)	208 (58.3%)	133 (58.6%)
N1	162 (27.7%)	92 (25.8%)	70 (30.8%)
N2	81 (13.9%)	57 (16.0%)	24 (10.6%)
Tumor stage				0.213	0.899
I	125 (21.4%)	78 (21.8%)	47 (20.7%)
II	215 (36.8%)	129 (36.1%)	86 (37.9%)
III	244 (41.8%)	150 (42.0%)	94 (41.4%)
Tumor location				21.511	<0.001
Rectal	317 (54.3%)	221 (61.9%)	96 (42.3%)
Colon	267 (45.7%)	136 (38.1%)	131 (57.7%)
Perineural invasion				0.125	0.724
Negative	533 (91.3%)	327 (91.6%)	206 (90.7%)
Positive	51 (8.7%)	30 (8.4%)	21 (9.3%)
Vascular invasion
Negative	501 (85.8%)	316 (88.5%)	185 (81.5%)	5.605	0.018
Positive	83 (14.2%)	41 (11.5%)	42 (18.5%)
Pathological type				2.139	0.343
Protrude type	117 (20.0%)	68 (19.0%)	49 (21.6%)
Infiltrating type	69 (11.8%)	38 (10.6%)	31 (13.7%)
Ulcerative type	398 (68.2%)	251 (70.3%)	147 (64.8%)
Histological grade				0.834	0.361
Low	61 (10.4%)	34 (9.5%)	27 (11.9%)
High	523 (89.6%)	323 (90.5%)	200 (88.1%)
Tumor size				8.591	<0.001
ASA classification				0.291	0.590
I-II	322 (55.1%)	200 (56.0%)	122 (53.7%)
III-IV	262 (44.9%)	157 (44.0%)	105 (46.3%)
CEA				6.451	0.011
Normal	369 (63.2%)	240 (67.2%)	129 (56.8%)
High	215 (36.8%)	117 (32.8%)	98 (43.2%)
Length of hospitalization				1.248	0.213
Albumin				-12.164	<0.001
Prealbumin				-20.686	<0.001
Fibrinogen				17.364	<0.001
PNI				8.689	<0.001
NLR				5.389	<0.001
LMR				-6.776	<0.001
PLR				30.271	<0.001
Postoperative complications ()	69 (11.8%)	32 (9.0%)	37 (16.3%)	7.167	0.007