Prognostic Significance of Preoperative Fibrinogen-to-Prealbumin Ratio in Patients with Stage I–III Colorectal Cancer Undergoing Surgical Resection: A Retrospective Cohort Study

Table 2

The correlations between the postoperative complications and various clinicopathological factors.

Variable	Postoperative complication
	Univariate		Multivariate
	HR (95% CI)	value	HR (95% CI)	value
Gender (female)	0.801 (0.471-1.361)	0.412
Age (years) (≥60)	1.675 (1.002-2.799)	0.049	1.311 (0.756-2.273)	0.335	0.271
BMI		0.876
Low	1
Normal	1.071 (0.514-2.232)
High	0.916 (0.400-2.100)
Diabetes mellitus (positive)	1.867 (0.737-4.726)	0.188
Hypertension (positive)	2.103 (1.165-3.798)	0.014	1.843 (0.984-3.450)	0.056	0.611
Cardiovascular disease (positive)	1.251 (0.274-5.712)	0.772
Depth of invasion (T3-4)	1.031 (0.588-1.809)	0.914
Lymph node status		0.987
N0	1.000
N1	1.000 (0.559-1.788)
N2	1.060 (0.506-2.221)
Tumor location (colon)	0.844 (0.507-1.403)	0.513
Perineural invasion (positive)	1.209 (0.522-2.801)	0.659
Vascular invasion (positive)	1.476 (0.767-2.838)	0.243
Pathological type		0.693
Protrude type	1.000
Infiltrating type	0.701 (0.256-1.917)
Ulcerative type	1.033 (0.548-1.946)
Histological grade (low)	1.764 (0.869-3.579)	0.116
Tumor size (≥5 cm)	1.614 (0.968-2.689)	0.066
CEA (high)	0.972 (0.576-1.639)	0.915
ASA grade (III-IV)	1.072 (0.647-1.774)	0.788
Type of surgery (open)	1.041 (0.630-1.722)	0.874
Albumin (low)	1.278 (0.743-2.196)	0.375
Prealbumin (low)	1.200 (0.704-2.044)	0.502
Fibrinogen (high)	1.233 (0.883-1.720)	0.219
FPR (high)	1.978 (1.193-3.280)	0.008	1.785 (1.062-2.999)	0.029	0.579
PNI (low)	1.540 (0.924-2.566)	0.097
NLR (high)	1.104 (0.667-1.825)	0.701
LMR (high)	0.649 (0.390-1.082)	0.097
PLR (high)	1.440 (0.866-2.393)	0.160
Blood loss (≥100 mL)	2.034 (1.204-3.438)	0.008	1.956 (1.151-3.326)	0.013	0.671
Operation time (≥209 min)	1.540 (0.924-2.566)	0.097