Prognostic Significance of Preoperative Fibrinogen-to-Prealbumin Ratio in Patients with Stage I–III Colorectal Cancer Undergoing Surgical Resection: A Retrospective Cohort Study

Table 3

The correlations between the disease-free survival and various clinicopathological factors.

Variable	Disease-free survival
	Univariate		Multivariate
	HR (95% CI)	value	HR (95% CI)	value
Gender (female)	0.873 (0.652-1.168)	0.360
Age (years) (≥60)	1.255 (0.949-1.659)	0.111
BMI		0.736
Low	1
Normal	1.120 (0.742-1.689)
High	0.999 (0.629-1.587)
Diabetes mellitus (positive)	1.132 (0.631-2.029)	0.678
Hypertension (positive)	1.229 (0.860-1.756)	0.258
Cardiovascular disease (positive)	1.242 (0.461-3.342)	0.668
Depth of invasion (T3-4)	1.951 (1.365-2.789)	<0.001	1.320 (0.907-1.922)	0.147
Lymph node status		<0.001		<0.001
N0	1.000		1.000
N1	1.661 (1.190-2.320)		1.378 (0.958-1.983)
N2	4.771 (3.399-6.697)		3.922 (2.590-5.938)
Tumor location (colon)	0.852 (0.643-1.129)	0.266
Perineural invasion (positive)	1.688 (1.109-2.567)	0.014	1.192 (0.748-1.899)	0.460
Vascular invasion (positive)	1.882 (1.338-2.646)	<0.001	1.188 (0.805-1.753)	0.385
Pathological type		0.335
Protrude type	1.000
Infiltrating type	1.285 (0.760-2.175)
Ulcerative type	1.330 (0.911-1.943)
Histological grade (low)	1.799 (1.226-2.640)	0.003	1.310 (0.883-1.943)	0.179
Maximum tumor size (≥5)	1.234 (0.934-1.630)	0.140
CEA (high)	1.738 (1.315-2.296)	<0.001	1.507 (1.133-2.004)	0.005
ASA grade (III-IV)	1.919 (1.449-2.542)	<0.001	1.139 (0.822-1.578)	0.435
Type of surgery (open)	0.906 (0.686-1.197)	0.486
Postoperative chemotherapy (yes)	1.019 (0.772-1.345)	0.896
Albumin (low)	1.112 (0.781-1.584)	0.555
Prealbumin (low)	1.051 (0.745-1.481)	0.778
Fibrinogen (high)	1.163 (0.841-1.610)	0.362
FPR (high)	1.365 (1.032-1.806)	0.029	1.459 (1.074-1.954)	0.011
PNI (low)	1.003 (0.760-1.325)	0.982
NLR (high)	1.061 (0.803-1.401)	0.677
LMR (high)	0.869 (0.658-1.148)	0.324
PLR (high)	1.003 (0.760-1.325)	0.982
Blood loss (≥100 mL)	1.110 (0.840-1.466)	0.464
Operation time (≥209 min)	1.224 (0.926-1.618)	0.155