Prognostic Significance of Preoperative Fibrinogen-to-Prealbumin Ratio in Patients with Stage I–III Colorectal Cancer Undergoing Surgical Resection: A Retrospective Cohort Study

Table 4

The correlations between the overall survival and various clinicopathological factors.

Variable	Overall survival
	Univariate		Multivariate
	HR (95% CI)	value	HR (95% CI)	value
Gender (female)	0.843 (0.622-1.142)	0.270
Age (years) (≥60)	1.407 (1.051-1.883)	0.022	1.529 (1.122-2.086)	0.007
BMI		0.765
Low	1
Normal	1.001 (0.629-1.592)
High	1.004 (0.717-1.408)
Diabetes mellitus (positive)	1.115 (0.571-2.179)	0.750
Hypertension (positive)	1.216 (0.838-1.763)	0.304
Cardiovascular disease (positive)	1.590 (0.508-4.975)	0.426
Depth of invasion (T3-4)	2.008 (1.378-2.926)	<0.001	1.409 (0.947-2.098)	0.091
Lymph node status		<0.001		<0.001
N0	1.000		1.000
N1	1.624 (1.145-2.302)		1.434 (0.978-2.103)
N2	4.805 (3.389-6.813)		4.309 (2.797-6.638)
Tumor location (colon)	0.815 (0.608-1.093)	0.172
Perineural invasion (positive)	1.487 (0.944-2.343)	0.087
Vascular invasion (positive)	1.751 (1.226-2.502)	0.002	1.112 (0.763-1.621)	0.581
Pathological type		0.329
Protrude type	1.000
Infiltrating type	1.413 (0.826-2.418)
Ulcerative type	1.325 (0.891-1.971)
Histological grade (low)	1.919 (1.298-2.838)	0.001	1.495 (0.994-2.248)	0.053
Maximum tumor size (≥5)	1.298 (0.972-1.733)	0.077
CEA (high)	1.698 (1.272-2.267)	<0.001	1.400 (1.038-1.890)	0.028
ASA grade (III-IV)	1.990 (1.485-2.666)	<0.001	1.104 (0.783-1.558)	0.572
Type of surgery (open)	1.122 (0.841-1.497)	0.435
Postoperative chemotherapy (yes)	1.003 (0.752-1.339)	0.981
Albumin (low)	1.173 (0.808-1.701)	0.401
Prealbumin (low)	1.067 (0.747-1.524)	0.723
Fibrinogen (high)	1.233 (0.883-1.720)	0.219
FPR (high)	1.383 (1.035-1.848)	0.028	1.405 (1.034-1.909)	0.030
PNI (low)	1.048 (0.785-1.398)	0.751
NLR (high)	1.031 (0.773-1.376)	0.835
LMR (high)	0.891 (0.668-1.189)	0.434
PLR (high)	1.001 (0.750-1.334)	0.999
Blood loss (≥100 mL)	1.155 (0.865-1.542)	0.327
Operation time (≥209 min)	1.286 (0.962-1.718)	0.090